An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation

Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number732917
Number of pages21
JournalFrontiers in bioengineering and biotechnology
Volume9
DOIs
Publication statusPublished - 15 Nov 2021

Keywords

  • computational model
  • signal transduction
  • IGF
  • BMP7
  • PTHrP
  • chondrogenesis
  • hypertrophy
  • HORMONE-RELATED PEPTIDE
  • BIOLOGICAL PATHWAY DYNAMICS
  • ARTICULAR-CARTILAGE
  • CHONDROCYTE DIFFERENTIATION
  • PROTEIN-PHOSPHORYLATION
  • JOINT FORMATION
  • GROWTH-PLATE
  • BONE
  • CHONDROGENESIS
  • SOX9

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