Association between blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents

Inge Van der Wurff*, Clemens Von Schacky, Kjetil Berge, Maurice Zeegers, Paul A. Kirschner, Renate De Groot

*Corresponding author for this work

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Abstract

The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13–15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83% (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = −0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index.
Original languageEnglish
Number of pages14
JournalNutrients
Volume8
Issue number1
DOIs
Publication statusPublished - 2 Jan 2016

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Unsaturated Fatty Acids
cognition
Cognition
Euphausiacea
Regression Analysis
Stroop Test
Impulsive Behavior
Neuropsychological Tests
blood
Automatic Data Processing
Fingers
Oils
long chain polyunsaturated fatty acids
Placebos
testing
krill
placebos
oils

Keywords

  • docosahexaneoic acid
  • eicosapentaenoic acid
  • adolescents
  • cognition
  • Omega-3 fatty acids
  • Omega-3 Index

Cite this

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title = "Association between blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents",
abstract = "The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13–15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83{\%} (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = −0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index.",
keywords = "docosahexaneoic acid, eicosapentaenoic acid, adolescents, cognition, Omega-3 fatty acids, Omega-3 Index",
author = "{Van der Wurff}, Inge and {Von Schacky}, Clemens and Kjetil Berge and Maurice Zeegers and Kirschner, {Paul A.} and {De Groot}, Renate",
year = "2016",
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journal = "Nutrients",
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Association between blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents. / Van der Wurff, Inge; Von Schacky, Clemens; Berge, Kjetil; Zeegers, Maurice; Kirschner, Paul A.; De Groot, Renate.

In: Nutrients, Vol. 8, No. 1, 02.01.2016.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Association between blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents

AU - Van der Wurff, Inge

AU - Von Schacky, Clemens

AU - Berge, Kjetil

AU - Zeegers, Maurice

AU - Kirschner, Paul A.

AU - De Groot, Renate

PY - 2016/1/2

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N2 - The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13–15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83% (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = −0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index.

AB - The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13–15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83% (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = −0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index.

KW - docosahexaneoic acid

KW - eicosapentaenoic acid

KW - adolescents

KW - cognition

KW - Omega-3 fatty acids

KW - Omega-3 Index

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