Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age: the MEFAB birth cohort

Elske Brouwer-Brolsma*, Ondine Van de Rest, Roger Godschalk, Marij Zeegers, M. Gielen, Renate De Groot

*Corresponding author for this work

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Abstract

Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning. Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort. Maternal AA, DHA, and EPA were determined in plasma phospholipids - obtained in three trimesters - by gas-liquid chromatography. Cognitive function was assessed at 7 years of age, using the Kaufman Assessment Battery for Children, resulting in three main outcome parameters: sequential processing (short-term memory), simultaneous processing (problem-solving skills), and the mental processing composite score. Spline regression and linear regression analyses were used to analyse the data, while adjusting for potential relevant covariates. Only 2% of the children performed more than one SD below the mental processing composite norm score. Children with lower test scores (<25%) were more likely to have a younger mother with a higher pre-gestational BMI, less likely to be breastfed, and more likely to be born with a lower birth weight, compared to children with higher test scores (≥25%). Fully-adjusted linear regression models did not show associations of maternal AA, DHA, or EPA status during any of the pregnancy trimesters with childhood sequential and simultaneous processing. Maternal fatty acid status during pregnancy was not associated with cognitive performance in Dutch children at age 7.
Original languageEnglish
Pages (from-to)92-97
JournalProstaglandins, Leukotrienes, & Essential Fatty Acids
Volume126
DOIs
Publication statusPublished - 1 Sep 2017

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Unsaturated Fatty Acids
Cognition
Mothers
Parturition
Linear Models
Fatty Acids
Pregnancy Trimesters
Pregnancy
Brain
Third Pregnancy Trimester
Fetal Development
Short-Term Memory
Birth Weight
Gas Chromatography
Phospholipids
Fishes
Regression Analysis

Keywords

  • LCPUFA
  • cognitive performance
  • maternal
  • childhood
  • offspring

Cite this

@article{fa7b3edb75c940938df33047b993cc5e,
title = "Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age: the MEFAB birth cohort",
abstract = "Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning. Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort. Maternal AA, DHA, and EPA were determined in plasma phospholipids - obtained in three trimesters - by gas-liquid chromatography. Cognitive function was assessed at 7 years of age, using the Kaufman Assessment Battery for Children, resulting in three main outcome parameters: sequential processing (short-term memory), simultaneous processing (problem-solving skills), and the mental processing composite score. Spline regression and linear regression analyses were used to analyse the data, while adjusting for potential relevant covariates. Only 2{\%} of the children performed more than one SD below the mental processing composite norm score. Children with lower test scores (<25{\%}) were more likely to have a younger mother with a higher pre-gestational BMI, less likely to be breastfed, and more likely to be born with a lower birth weight, compared to children with higher test scores (≥25{\%}). Fully-adjusted linear regression models did not show associations of maternal AA, DHA, or EPA status during any of the pregnancy trimesters with childhood sequential and simultaneous processing. Maternal fatty acid status during pregnancy was not associated with cognitive performance in Dutch children at age 7.",
keywords = "LCPUFA, cognitive performance, maternal, childhood, offspring",
author = "Elske Brouwer-Brolsma and {Van de Rest}, Ondine and Roger Godschalk and Marij Zeegers and M. Gielen and {De Groot}, Renate",
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language = "English",
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pages = "92--97",
journal = "Prostaglandins, Leukotrienes, & Essential Fatty Acids",
publisher = "Prostaglandins, Leukotrienes, & Essential Fatty Acids",

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Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age : the MEFAB birth cohort. / Brouwer-Brolsma, Elske; Van de Rest, Ondine; Godschalk, Roger; Zeegers, Marij; Gielen, M.; De Groot, Renate.

In: Prostaglandins, Leukotrienes, & Essential Fatty Acids, Vol. 126, 01.09.2017, p. 92-97.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age

T2 - the MEFAB birth cohort

AU - Brouwer-Brolsma, Elske

AU - Van de Rest, Ondine

AU - Godschalk, Roger

AU - Zeegers, Marij

AU - Gielen, M.

AU - De Groot, Renate

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning. Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort. Maternal AA, DHA, and EPA were determined in plasma phospholipids - obtained in three trimesters - by gas-liquid chromatography. Cognitive function was assessed at 7 years of age, using the Kaufman Assessment Battery for Children, resulting in three main outcome parameters: sequential processing (short-term memory), simultaneous processing (problem-solving skills), and the mental processing composite score. Spline regression and linear regression analyses were used to analyse the data, while adjusting for potential relevant covariates. Only 2% of the children performed more than one SD below the mental processing composite norm score. Children with lower test scores (<25%) were more likely to have a younger mother with a higher pre-gestational BMI, less likely to be breastfed, and more likely to be born with a lower birth weight, compared to children with higher test scores (≥25%). Fully-adjusted linear regression models did not show associations of maternal AA, DHA, or EPA status during any of the pregnancy trimesters with childhood sequential and simultaneous processing. Maternal fatty acid status during pregnancy was not associated with cognitive performance in Dutch children at age 7.

AB - Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning. Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort. Maternal AA, DHA, and EPA were determined in plasma phospholipids - obtained in three trimesters - by gas-liquid chromatography. Cognitive function was assessed at 7 years of age, using the Kaufman Assessment Battery for Children, resulting in three main outcome parameters: sequential processing (short-term memory), simultaneous processing (problem-solving skills), and the mental processing composite score. Spline regression and linear regression analyses were used to analyse the data, while adjusting for potential relevant covariates. Only 2% of the children performed more than one SD below the mental processing composite norm score. Children with lower test scores (<25%) were more likely to have a younger mother with a higher pre-gestational BMI, less likely to be breastfed, and more likely to be born with a lower birth weight, compared to children with higher test scores (≥25%). Fully-adjusted linear regression models did not show associations of maternal AA, DHA, or EPA status during any of the pregnancy trimesters with childhood sequential and simultaneous processing. Maternal fatty acid status during pregnancy was not associated with cognitive performance in Dutch children at age 7.

KW - LCPUFA

KW - cognitive performance

KW - maternal

KW - childhood

KW - offspring

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DO - 10.1016/j.plefa.2017.09.012

M3 - Article

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JO - Prostaglandins, Leukotrienes, & Essential Fatty Acids

JF - Prostaglandins, Leukotrienes, & Essential Fatty Acids

ER -