Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk

A 3-Year Follow-up Study

Patrick Domen*, Sanne Peeters, Stijn Michielse, Ed Gronenschild, Wolfgang Viechtbauer, Alard Roebroeck, Jim van Os, Machteld Marcelis, Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability.

METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics. The mean fractional anisotropy (FA) change over time was calculated. Main effects of group, as well as group × region interactions in the model of FA change were examined with multilevel (mixed-effects) models.

RESULTS: Siblings revealed a significant mean FA decrease over time compared to controls (B = -0.004, P = .04), resulting in a significant sibling-control difference at follow-up (B = -0.007, P = .03). Patients did not show a significant change over time, but their mean FA was lower than controls both at baseline and at follow-up. A significant group × region interaction (χ2 = 105.4, P = .01) revealed group differences in FA change in the right cingulum, left posterior thalamic radiation, right retrolenticular part of the internal capsule, and the right posterior corona radiata.

CONCLUSION: Whole brain mean FA remained stable over a 3-year period in patients with psychotic disorder and declined over time in nonaffected siblings, so that at follow-up both groups had lower FA with respect to controls. The results suggest that liability for psychosis may involve a process of WM alterations.

Original languageEnglish
Pages (from-to)160-170
Number of pages11
JournalSchizophrenia Bulletin
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 2017

Fingerprint

Anisotropy
Psychotic Disorders
Siblings
Diffusion Tensor Imaging
Internal Capsule
White Matter
Schizophrenia
Radiation
Brain

Keywords

  • psychotic disorder
  • diffusion tensor imaging
  • disease progression
  • siblings
  • DIFFUSION TENSOR TRACTOGRAPHY
  • NEGATIVE-SYNDROME-SCALE
  • 1ST EPISODE PSYCHOSIS
  • LIFE-SPAN
  • DISCONNECTION SYNDROME
  • SPATIAL STATISTICS
  • BIPOLAR DISORDER
  • NAIVE PATIENTS
  • SCHIZOPHRENIA
  • INTEGRITY

Cite this

Domen, P., Peeters, S., Michielse, S., Gronenschild, E., Viechtbauer, W., Roebroeck, A., ... Genetic Risk and Outcome of Psychosis (G.R.O.U.P.) (2017). Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study. Schizophrenia Bulletin, 43(1), 160-170. https://doi.org/10.1093/schbul/sbw061
Domen, Patrick ; Peeters, Sanne ; Michielse, Stijn ; Gronenschild, Ed ; Viechtbauer, Wolfgang ; Roebroeck, Alard ; Os, Jim van ; Marcelis, Machteld ; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.). / Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk : A 3-Year Follow-up Study. In: Schizophrenia Bulletin. 2017 ; Vol. 43, No. 1. pp. 160-170.
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abstract = "BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability.METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics. The mean fractional anisotropy (FA) change over time was calculated. Main effects of group, as well as group × region interactions in the model of FA change were examined with multilevel (mixed-effects) models.RESULTS: Siblings revealed a significant mean FA decrease over time compared to controls (B = -0.004, P = .04), resulting in a significant sibling-control difference at follow-up (B = -0.007, P = .03). Patients did not show a significant change over time, but their mean FA was lower than controls both at baseline and at follow-up. A significant group × region interaction (χ2 = 105.4, P = .01) revealed group differences in FA change in the right cingulum, left posterior thalamic radiation, right retrolenticular part of the internal capsule, and the right posterior corona radiata.CONCLUSION: Whole brain mean FA remained stable over a 3-year period in patients with psychotic disorder and declined over time in nonaffected siblings, so that at follow-up both groups had lower FA with respect to controls. The results suggest that liability for psychosis may involve a process of WM alterations.",
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author = "Patrick Domen and Sanne Peeters and Stijn Michielse and Ed Gronenschild and Wolfgang Viechtbauer and Alard Roebroeck and Os, {Jim van} and Machteld Marcelis and {Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)}",
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Domen, P, Peeters, S, Michielse, S, Gronenschild, E, Viechtbauer, W, Roebroeck, A, Os, JV, Marcelis, M & Genetic Risk and Outcome of Psychosis (G.R.O.U.P.) 2017, 'Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study', Schizophrenia Bulletin, vol. 43, no. 1, pp. 160-170. https://doi.org/10.1093/schbul/sbw061

Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk : A 3-Year Follow-up Study. / Domen, Patrick; Peeters, Sanne; Michielse, Stijn; Gronenschild, Ed; Viechtbauer, Wolfgang; Roebroeck, Alard; Os, Jim van; Marcelis, Machteld; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.).

In: Schizophrenia Bulletin, Vol. 43, No. 1, 01.2017, p. 160-170.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk

T2 - A 3-Year Follow-up Study

AU - Domen, Patrick

AU - Peeters, Sanne

AU - Michielse, Stijn

AU - Gronenschild, Ed

AU - Viechtbauer, Wolfgang

AU - Roebroeck, Alard

AU - Os, Jim van

AU - Marcelis, Machteld

AU - Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)

N1 - © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2017/1

Y1 - 2017/1

N2 - BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability.METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics. The mean fractional anisotropy (FA) change over time was calculated. Main effects of group, as well as group × region interactions in the model of FA change were examined with multilevel (mixed-effects) models.RESULTS: Siblings revealed a significant mean FA decrease over time compared to controls (B = -0.004, P = .04), resulting in a significant sibling-control difference at follow-up (B = -0.007, P = .03). Patients did not show a significant change over time, but their mean FA was lower than controls both at baseline and at follow-up. A significant group × region interaction (χ2 = 105.4, P = .01) revealed group differences in FA change in the right cingulum, left posterior thalamic radiation, right retrolenticular part of the internal capsule, and the right posterior corona radiata.CONCLUSION: Whole brain mean FA remained stable over a 3-year period in patients with psychotic disorder and declined over time in nonaffected siblings, so that at follow-up both groups had lower FA with respect to controls. The results suggest that liability for psychosis may involve a process of WM alterations.

AB - BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability.METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics. The mean fractional anisotropy (FA) change over time was calculated. Main effects of group, as well as group × region interactions in the model of FA change were examined with multilevel (mixed-effects) models.RESULTS: Siblings revealed a significant mean FA decrease over time compared to controls (B = -0.004, P = .04), resulting in a significant sibling-control difference at follow-up (B = -0.007, P = .03). Patients did not show a significant change over time, but their mean FA was lower than controls both at baseline and at follow-up. A significant group × region interaction (χ2 = 105.4, P = .01) revealed group differences in FA change in the right cingulum, left posterior thalamic radiation, right retrolenticular part of the internal capsule, and the right posterior corona radiata.CONCLUSION: Whole brain mean FA remained stable over a 3-year period in patients with psychotic disorder and declined over time in nonaffected siblings, so that at follow-up both groups had lower FA with respect to controls. The results suggest that liability for psychosis may involve a process of WM alterations.

KW - psychotic disorder

KW - diffusion tensor imaging

KW - disease progression

KW - siblings

KW - DIFFUSION TENSOR TRACTOGRAPHY

KW - NEGATIVE-SYNDROME-SCALE

KW - 1ST EPISODE PSYCHOSIS

KW - LIFE-SPAN

KW - DISCONNECTION SYNDROME

KW - SPATIAL STATISTICS

KW - BIPOLAR DISORDER

KW - NAIVE PATIENTS

KW - SCHIZOPHRENIA

KW - INTEGRITY

U2 - 10.1093/schbul/sbw061

DO - 10.1093/schbul/sbw061

M3 - Article

VL - 43

SP - 160

EP - 170

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 1

ER -