Effect of one year krill oil supplementation on depressive symptoms and self-esteem of Dutch adolescents: a randomized controlled trial

I.S.M. van der Wurff, Clemens Von Schacky, Trygve Bergeland, R. Leontjevas, Maurice P Zeegers, P.A. Kirschner, R.H.M. de Groot

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction
Observational studies have shown a relationship between omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) and depression in adolescents. However, n-3 LCPUFA supplementation studies investigating the potential improvement in depressive feelings in adolescents from the general population are missing.

Methods
A one-year double-blind, randomized, placebo controlled krill oil supplementation trial was conducted in two cohorts. Cohort I started with 400mg eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) or placebo, after three months this increased to 800mg EPA and DHA per day, whilst cohort II started with this higher dose. Omega-3 Index (O3I) was monitored via finger-prick blood measurements. At baseline, six and 12 months participants completed the Centre for Epidemiologic Studies Depression Scale (CES-D) and the Rosenberg Self Esteem questionnaire (RSE). Adjusted mixed models were run with treatment allocation/O3I as predictor of CES-D and RSE scores.

Results
Both intention-to-treat and assessing the change in O3I analyses did not show significant effects on CES-D or RSE scores.

Conclusion
There is no evidence for less depressive feelings, or higher self-esteem after one year of krill oil supplementation. However, due to a lack of compliance and drop-out issues, these results should be interpreted with caution.
Original languageEnglish
Article number102208
JournalProstaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Volume163
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Adolescents
  • Depression
  • Long-chain polyunsaturated fatty acid
  • Self-esteem
  • Omega-3 Index

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