Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans

Sophie Hiel, Laure B. Bindels, Barbara D. Pachikian*, Gaetan Kalala, Valérie Broers, Giorgia Zamariola, Betty P.I. Chang, Bienvenu Kambashi, Julie Rodriguez, Patrice D. Cani, Audrey M. Neyrinck, Jean-Paul Thissen, Olivier Luminet, Jérôme Bindelle, Nathalie M. Delzenne

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate.

OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals.

METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms.

RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention.

CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550.

Original languageEnglish
Pages (from-to)1683-1695
Number of pages13
JournalAmerican Journal of Clinical Nutrition
Volume109
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019
Externally publishedYes

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Fructans
Inulin
Vegetables
Diet
Health
Food
Dietary Fiber
Oxalobacteraceae
Ruminococcus
Flatulence
Bifidobacterium
Pleasure
Clostridium
Microbiota
Fermentation
Volunteers
Eating
Gastrointestinal Microbiome

Cite this

Hiel, Sophie ; Bindels, Laure B. ; Pachikian, Barbara D. ; Kalala, Gaetan ; Broers, Valérie ; Zamariola, Giorgia ; Chang, Betty P.I. ; Kambashi, Bienvenu ; Rodriguez, Julie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Thissen, Jean-Paul ; Luminet, Olivier ; Bindelle, Jérôme ; Delzenne, Nathalie M. / Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. In: American Journal of Clinical Nutrition. 2019 ; Vol. 109, No. 6. pp. 1683-1695.
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title = "Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans",
abstract = "BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate.OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals.METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms.RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention.CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550.",
author = "Sophie Hiel and Bindels, {Laure B.} and Pachikian, {Barbara D.} and Gaetan Kalala and Val{\'e}rie Broers and Giorgia Zamariola and Chang, {Betty P.I.} and Bienvenu Kambashi and Julie Rodriguez and Cani, {Patrice D.} and Neyrinck, {Audrey M.} and Jean-Paul Thissen and Olivier Luminet and J{\'e}r{\^o}me Bindelle and Delzenne, {Nathalie M.}",
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Hiel, S, Bindels, LB, Pachikian, BD, Kalala, G, Broers, V, Zamariola, G, Chang, BPI, Kambashi, B, Rodriguez, J, Cani, PD, Neyrinck, AM, Thissen, J-P, Luminet, O, Bindelle, J & Delzenne, NM 2019, 'Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans', American Journal of Clinical Nutrition, vol. 109, no. 6, pp. 1683-1695. https://doi.org/10.1093/ajcn/nqz001

Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. / Hiel, Sophie; Bindels, Laure B.; Pachikian, Barbara D.; Kalala, Gaetan; Broers, Valérie; Zamariola, Giorgia; Chang, Betty P.I.; Kambashi, Bienvenu; Rodriguez, Julie; Cani, Patrice D.; Neyrinck, Audrey M.; Thissen, Jean-Paul; Luminet, Olivier; Bindelle, Jérôme; Delzenne, Nathalie M.

In: American Journal of Clinical Nutrition, Vol. 109, No. 6, 01.06.2019, p. 1683-1695.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans

AU - Hiel, Sophie

AU - Bindels, Laure B.

AU - Pachikian, Barbara D.

AU - Kalala, Gaetan

AU - Broers, Valérie

AU - Zamariola, Giorgia

AU - Chang, Betty P.I.

AU - Kambashi, Bienvenu

AU - Rodriguez, Julie

AU - Cani, Patrice D.

AU - Neyrinck, Audrey M.

AU - Thissen, Jean-Paul

AU - Luminet, Olivier

AU - Bindelle, Jérôme

AU - Delzenne, Nathalie M.

N1 - Copyright © American Society for Nutrition 2019.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate.OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals.METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms.RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention.CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550.

AB - BACKGROUND: Inulin-type fructans (ITFs) are a type of fermentable dietary fiber that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behavior is a matter of debate.OBJECTIVE: We evaluated the impact of consuming ITF-rich vegetables daily on gut microbiota, gastro-intestinal symptoms, and food-related behavior in healthy individuals.METHODS: A single group-design trial was conducted in 26 healthy individuals. During 2 wk, the participants were instructed to adhere to a controlled diet based on ITF-rich vegetables (providing a mean intake of 15 g ITF/d). Three test days were organized: before and after the nutritional intervention and 3 wk after returning to their usual diet. We assessed nutrient intake, food-related behavior, fecal microbiota composition, microbial fermentation, and gastrointestinal symptoms.RESULTS: The major microbial modifications during the intervention were an increased proportion of the Bifidobacterium genus, a decreased level of unclassified Clostridiales, and a tendency to decrease Oxalobacteraceae. These changes were reversed 3 wk after the intervention. The volunteers showed greater satiety, a reduced desire to eat sweet, salty, and fatty food, and a trend to increase hedonic attitudes towards some inulin-rich vegetables. Only flatulence episodes were reported during the dietary intervention, whereas intestinal discomfort, inversely associated with Clostridium cluster IV and Ruminococcus callidus, was improved at the end of the intervention.CONCLUSIONS: A higher consumption of ITF-rich vegetables allows a substantial increase in well-tolerated dietary fiber, which may in turn improve food-related behavior. Moreover, it leads to beneficial modifications of the gut microbiota composition and function. This trial is registered at clinicaltrial.gov as NCT03540550.

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DO - 10.1093/ajcn/nqz001

M3 - Article

C2 - 31108510

VL - 109

SP - 1683

EP - 1695

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -