Effects of prebiotics on affect and cognition in human intervention studies

Olivier Desmedt, Valérie J.V. Broers, Giorgia Zamariola, Barbara Pachikian, Nathalie Delzenne, Olivier Luminet*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Studies conducted in rodents have highlighted that neurobiological processes underlying cognition and affect are modulated by the gut microbiota. Certain dietary fibers are able to modulate the composition of gut microbiota and are thus considered prebiotics. A review of the impact of the available prebiotic intervention studies in humans on cognition and affect, addressing the potential mediating role of the microbiota, was conducted. PubMed, Scopus, and PsycINFO were selected as sources. Fourteen articles were eligible for narrative synthesis. Data extraction and quality assessment were performed with characteristics established a priori. Some chronic prebiotic interventions (>28 d) improved affect and verbal episodic memory compared with a placebo. Acute prebiotic interventions (<24 h) were more efficient in improving cognitive variables (eg, verbal episodic memory). Future research should measure microbiota using adequate methodologies and recruit patients with dysbiosis, inflammation, or psychopathology. More research is needed to unravel the conditions required to obtain effects on affect and cognition.

Original languageEnglish
Pages (from-to)81-95
Number of pages15
JournalNutrition Reviews
Volume77
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

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Prebiotics
Cognition
Episodic Memory
Microbiota
Dysbiosis
Dietary Fiber
Psychopathology
PubMed
Rodentia
Placebos
Inflammation
Research
Gastrointestinal Microbiome

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Desmedt, Olivier ; Broers, Valérie J.V. ; Zamariola, Giorgia ; Pachikian, Barbara ; Delzenne, Nathalie ; Luminet, Olivier. / Effects of prebiotics on affect and cognition in human intervention studies. In: Nutrition Reviews. 2019 ; Vol. 77, No. 2. pp. 81-95.
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Desmedt, O, Broers, VJV, Zamariola, G, Pachikian, B, Delzenne, N & Luminet, O 2019, 'Effects of prebiotics on affect and cognition in human intervention studies', Nutrition Reviews, vol. 77, no. 2, pp. 81-95. https://doi.org/10.1093/nutrit/nuy052

Effects of prebiotics on affect and cognition in human intervention studies. / Desmedt, Olivier; Broers, Valérie J.V.; Zamariola, Giorgia; Pachikian, Barbara; Delzenne, Nathalie; Luminet, Olivier.

In: Nutrition Reviews, Vol. 77, No. 2, 01.02.2019, p. 81-95.

Research output: Contribution to journalArticleAcademicpeer-review

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