Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease

Sabrine Hassane, Wouter N Leonhard, Annemieke van der Wal, Lukas Jac Hawinkels, Irma S Lantinga-van Leeuwen, Peter ten Dijke, Martijn H Breuning, Emile de Heer, Dorien Jm Peters

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Web of Science)
Original languageEnglish
Pages (from-to)21-31
Number of pages11
JournalJournal of Pathology
Volume222
Issue number1
DOIs
Publication statusPublished - Sept 2010
Externally publishedYes

Keywords

  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Fibrosis/genetics
  • Gene Expression Regulation/physiology
  • Humans
  • Kidney/pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Polycystic Kidney Diseases/metabolism
  • RNA, Messenger/genetics
  • Signal Transduction/physiology
  • Smad Proteins/genetics
  • TRPP Cation Channels/genetics
  • Transforming Growth Factor beta/genetics

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