Evidence that reduced gray matter volume in psychotic disorder is associated with exposure to environmental risk factors

Aleida Frissen, Jim van Os, Sanne Peeters, Ed Gronenschild, Machteld Marcelis*, Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The aim of this study was to examine whether cannabis use, childhood trauma and urban upbringing are associated with total gray matter volume (GMV) in individuals with (risk for) psychotic disorder and whether this is sex-specific. T1-weighted MRI scans were acquired from 89 patients with a psychotic disorder, 95 healthy siblings of patients with psychotic disorder and 87 controls. Multilevel random regression analyses were used to examine main effects and interactions between group, sex and environmental factors in models of GMV. The three-way interaction between group, sex and cannabis (χ2 =12.43, p<0.01), as well as developmental urbanicity (χ2 = 6.29, p = 0.01) were significant, indicating that cannabis use and developmental urbanicity were associated with lower GMV in the male patient group (cannabis: B= -32.54, p < 0.01; developmental urbanicity: B= -10.23, p=0.03). For childhood trauma, the two-way interaction with group was significant (χ2 = 5.74, p = 0.02), indicating that childhood trauma was associated with reduced GMV in the patient group (B=-9.79, p=0.01). The findings suggest that reduction of GMV in psychotic disorder may be the outcome of differential sensitivity to environmental risks, particularly in male patients.

Original languageEnglish
Pages (from-to)100-110
Number of pages11
JournalPsychiatry Research-Neuroimaging
Volume271
DOIs
Publication statusPublished - 30 Jan 2018

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Environmental Exposure
Psychotic Disorders
Cannabis
Wounds and Injuries
Sex Factors
Siblings
Regression Analysis
Magnetic Resonance Imaging
Gray Matter

Keywords

  • 1ST-EPISODE SCHIZOPHRENIA-PATIENTS
  • CANNABIS USE
  • CHILDHOOD SEXUAL-ABUSE
  • CORTICAL THICKNESS
  • Cannabis
  • Childhood trauma
  • GENDER-DIFFERENCES
  • GEOMETRICALLY ACCURATE
  • Gene-environment interaction
  • Gray matter
  • HUMAN CEREBRAL-CORTEX
  • MAGNETIC-RESONANCE IMAGES
  • NEGATIVE-SYNDROME-SCALE
  • Psychotic disorder
  • SURFACE-BASED ANALYSIS
  • Urbanization

Cite this

Frissen, Aleida ; van Os, Jim ; Peeters, Sanne ; Gronenschild, Ed ; Marcelis, Machteld ; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.). / Evidence that reduced gray matter volume in psychotic disorder is associated with exposure to environmental risk factors. In: Psychiatry Research-Neuroimaging. 2018 ; Vol. 271. pp. 100-110.
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abstract = "The aim of this study was to examine whether cannabis use, childhood trauma and urban upbringing are associated with total gray matter volume (GMV) in individuals with (risk for) psychotic disorder and whether this is sex-specific. T1-weighted MRI scans were acquired from 89 patients with a psychotic disorder, 95 healthy siblings of patients with psychotic disorder and 87 controls. Multilevel random regression analyses were used to examine main effects and interactions between group, sex and environmental factors in models of GMV. The three-way interaction between group, sex and cannabis (χ2 =12.43, p<0.01), as well as developmental urbanicity (χ2 = 6.29, p = 0.01) were significant, indicating that cannabis use and developmental urbanicity were associated with lower GMV in the male patient group (cannabis: B= -32.54, p < 0.01; developmental urbanicity: B= -10.23, p=0.03). For childhood trauma, the two-way interaction with group was significant (χ2 = 5.74, p = 0.02), indicating that childhood trauma was associated with reduced GMV in the patient group (B=-9.79, p=0.01). The findings suggest that reduction of GMV in psychotic disorder may be the outcome of differential sensitivity to environmental risks, particularly in male patients.",
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author = "Aleida Frissen and {van Os}, Jim and Sanne Peeters and Ed Gronenschild and Machteld Marcelis and {Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)}",
note = "Copyright {\circledC} 2017. Published by Elsevier B.V.",
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Evidence that reduced gray matter volume in psychotic disorder is associated with exposure to environmental risk factors. / Frissen, Aleida; van Os, Jim; Peeters, Sanne; Gronenschild, Ed; Marcelis, Machteld; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.).

In: Psychiatry Research-Neuroimaging, Vol. 271, 30.01.2018, p. 100-110.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Evidence that reduced gray matter volume in psychotic disorder is associated with exposure to environmental risk factors

AU - Frissen, Aleida

AU - van Os, Jim

AU - Peeters, Sanne

AU - Gronenschild, Ed

AU - Marcelis, Machteld

AU - Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)

N1 - Copyright © 2017. Published by Elsevier B.V.

PY - 2018/1/30

Y1 - 2018/1/30

N2 - The aim of this study was to examine whether cannabis use, childhood trauma and urban upbringing are associated with total gray matter volume (GMV) in individuals with (risk for) psychotic disorder and whether this is sex-specific. T1-weighted MRI scans were acquired from 89 patients with a psychotic disorder, 95 healthy siblings of patients with psychotic disorder and 87 controls. Multilevel random regression analyses were used to examine main effects and interactions between group, sex and environmental factors in models of GMV. The three-way interaction between group, sex and cannabis (χ2 =12.43, p<0.01), as well as developmental urbanicity (χ2 = 6.29, p = 0.01) were significant, indicating that cannabis use and developmental urbanicity were associated with lower GMV in the male patient group (cannabis: B= -32.54, p < 0.01; developmental urbanicity: B= -10.23, p=0.03). For childhood trauma, the two-way interaction with group was significant (χ2 = 5.74, p = 0.02), indicating that childhood trauma was associated with reduced GMV in the patient group (B=-9.79, p=0.01). The findings suggest that reduction of GMV in psychotic disorder may be the outcome of differential sensitivity to environmental risks, particularly in male patients.

AB - The aim of this study was to examine whether cannabis use, childhood trauma and urban upbringing are associated with total gray matter volume (GMV) in individuals with (risk for) psychotic disorder and whether this is sex-specific. T1-weighted MRI scans were acquired from 89 patients with a psychotic disorder, 95 healthy siblings of patients with psychotic disorder and 87 controls. Multilevel random regression analyses were used to examine main effects and interactions between group, sex and environmental factors in models of GMV. The three-way interaction between group, sex and cannabis (χ2 =12.43, p<0.01), as well as developmental urbanicity (χ2 = 6.29, p = 0.01) were significant, indicating that cannabis use and developmental urbanicity were associated with lower GMV in the male patient group (cannabis: B= -32.54, p < 0.01; developmental urbanicity: B= -10.23, p=0.03). For childhood trauma, the two-way interaction with group was significant (χ2 = 5.74, p = 0.02), indicating that childhood trauma was associated with reduced GMV in the patient group (B=-9.79, p=0.01). The findings suggest that reduction of GMV in psychotic disorder may be the outcome of differential sensitivity to environmental risks, particularly in male patients.

KW - 1ST-EPISODE SCHIZOPHRENIA-PATIENTS

KW - CANNABIS USE

KW - CHILDHOOD SEXUAL-ABUSE

KW - CORTICAL THICKNESS

KW - Cannabis

KW - Childhood trauma

KW - GENDER-DIFFERENCES

KW - GEOMETRICALLY ACCURATE

KW - Gene-environment interaction

KW - Gray matter

KW - HUMAN CEREBRAL-CORTEX

KW - MAGNETIC-RESONANCE IMAGES

KW - NEGATIVE-SYNDROME-SCALE

KW - Psychotic disorder

KW - SURFACE-BASED ANALYSIS

KW - Urbanization

U2 - 10.1016/j.pscychresns.2017.11.004

DO - 10.1016/j.pscychresns.2017.11.004

M3 - Article

VL - 271

SP - 100

EP - 110

JO - Psychiatry Research-Neuroimaging

JF - Psychiatry Research-Neuroimaging

SN - 0925-4927

ER -