Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education

I.S.M. van der Wurff, Clemens Von Schacky, Trygve Bergeland, R. Leontjevas, Maurice Zeegers, P.A. Kirschner, R.H.M. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE). Methods Baseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE). Results Scores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95% credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95% CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95% CI contained 0, i.e., no significant association. Conclusion No evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.
Original languageEnglish
Pages (from-to)1429–1439
Number of pages11
JournalEuropean Journal of Nutrition
Volume58
Issue number4
Early online date16 Mar 2018
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Adolescents
  • depressed mood
  • Long-chain polyunsaturated fatty acid
  • Self-esteem
  • Omega-3 Index
  • Brain functioning
  • SUBTHRESHOLD DEPRESSION
  • PUBERTAL STATUS
  • Healthy youth
  • MENTAL-HEALTH
  • MAJOR DEPRESSION
  • Depressed mood
  • STRESSFUL LIFE EVENTS
  • High schoolers
  • DOCOSAHEXAENOIC ACID
  • DOUBLE-BLIND
  • POLYUNSATURATED FATTY-ACIDS
  • ITEM RESPONSE THEORY
  • EICOSAPENTAENOIC ACID

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