Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education

I.S.M. van der Wurff, Clemens Von Schacky, Trygve Bergeland, R. Leontjevas, Maurice Zeegers, P.A. Kirschner, R.H.M. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE). Methods Baseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE). Results Scores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95% credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95% CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95% CI contained 0, i.e., no significant association. Conclusion No evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.
Original languageEnglish
Pages (from-to)1429–1439
Number of pages11
JournalEuropean Journal of Nutrition
Volume58
Issue number4
Early online date16 Mar 2018
DOIs
Publication statusPublished - Jun 2019

Fingerprint

Eicosapentaenoic Acid
Docosahexaenoic Acids
Arachidonic Acid
Self Concept
Depression
Education
Unsaturated Fatty Acids
Epidemiologic Studies
Fatty Acids
Euphausiacea
docosapentaenoic acid
Omega-3 Fatty Acids
Research
Oils
Acids

Keywords

  • Adolescents
  • depressed mood
  • Long-chain polyunsaturated fatty acid
  • Self-esteem
  • Omega-3 Index
  • Brain functioning
  • SUBTHRESHOLD DEPRESSION
  • PUBERTAL STATUS
  • Healthy youth
  • MENTAL-HEALTH
  • MAJOR DEPRESSION
  • Depressed mood
  • STRESSFUL LIFE EVENTS
  • High schoolers
  • DOCOSAHEXAENOIC ACID
  • DOUBLE-BLIND
  • POLYUNSATURATED FATTY-ACIDS
  • ITEM RESPONSE THEORY
  • EICOSAPENTAENOIC ACID

Cite this

@article{5a19815c5deb4e85bb0ab8a260cdf29b,
title = "Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education",
abstract = "Purpose Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE). Methods Baseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5{\%} were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE). Results Scores indicative of depression (CES-D ≥ 16) were found in 29.4{\%} of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95{\%} credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95{\%} CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95{\%} CI contained 0, i.e., no significant association. Conclusion No evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5{\%}. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.",
keywords = "Adolescents, depressed mood, Long-chain polyunsaturated fatty acid, Self-esteem, Omega-3 Index, Brain functioning, SUBTHRESHOLD DEPRESSION, PUBERTAL STATUS, Healthy youth, MENTAL-HEALTH, MAJOR DEPRESSION, Depressed mood, STRESSFUL LIFE EVENTS, High schoolers, DOCOSAHEXAENOIC ACID, DOUBLE-BLIND, POLYUNSATURATED FATTY-ACIDS, ITEM RESPONSE THEORY, EICOSAPENTAENOIC ACID",
author = "{van der Wurff}, I.S.M. and {Von Schacky}, Clemens and Trygve Bergeland and R. Leontjevas and Maurice Zeegers and P.A. Kirschner and {de Groot}, R.H.M.",
year = "2019",
month = "6",
doi = "10.1007/s00394-018-1667-4",
language = "English",
volume = "58",
pages = "1429–1439",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "D. Steinkopff-Verlag",
number = "4",

}

Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education. / van der Wurff, I.S.M.; Von Schacky, Clemens; Bergeland, Trygve; Leontjevas, R.; Zeegers, Maurice; Kirschner, P.A.; de Groot, R.H.M.

In: European Journal of Nutrition, Vol. 58, No. 4, 06.2019, p. 1429–1439.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education

AU - van der Wurff, I.S.M.

AU - Von Schacky, Clemens

AU - Bergeland, Trygve

AU - Leontjevas, R.

AU - Zeegers, Maurice

AU - Kirschner, P.A.

AU - de Groot, R.H.M.

PY - 2019/6

Y1 - 2019/6

N2 - Purpose Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE). Methods Baseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE). Results Scores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95% credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95% CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95% CI contained 0, i.e., no significant association. Conclusion No evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.

AB - Purpose Depression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE). Methods Baseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE). Results Scores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95% credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95% CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95% CI contained 0, i.e., no significant association. Conclusion No evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.

KW - Adolescents

KW - depressed mood

KW - Long-chain polyunsaturated fatty acid

KW - Self-esteem

KW - Omega-3 Index

KW - Brain functioning

KW - SUBTHRESHOLD DEPRESSION

KW - PUBERTAL STATUS

KW - Healthy youth

KW - MENTAL-HEALTH

KW - MAJOR DEPRESSION

KW - Depressed mood

KW - STRESSFUL LIFE EVENTS

KW - High schoolers

KW - DOCOSAHEXAENOIC ACID

KW - DOUBLE-BLIND

KW - POLYUNSATURATED FATTY-ACIDS

KW - ITEM RESPONSE THEORY

KW - EICOSAPENTAENOIC ACID

U2 - 10.1007/s00394-018-1667-4

DO - 10.1007/s00394-018-1667-4

M3 - Article

VL - 58

SP - 1429

EP - 1439

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 4

ER -