Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: A pooled analysis of 18 European and US birth cohorts

Nikos Stratakis, Theano Roumeliotaki, Emily Oken, Ferran Ballester, Henrique Barros, Mikel Basterrechea, Sylvaine Cordier, Renate De Groot, Herman T. de Dekker, Liesbeth Duijts, Merete Eggesbø, Maria Pia Fantini, Francesco Forastiere, Ulrike Gehring, Marij Gielen, Davide Gori, Eva Govarts, Hazel M. Inskip, Nina Iszatt, Maria JansenCecily Kelleher, John Mehegan, Carolina Moltó-Puigmartí, Monique Mommers, Andrea Oliveira, Sjurdur F. Olsen, Fabienne Pelé, Constanza Pizzi, Daniela Porta, Lorenzo Richiardi, Sheryl L. Rifas-Shiman, Sian M. Robinson, Greet Schoeters, Marin Strøm, Jordi Sunyer, Carel Thijs, Martine Vrijheid, Tanja G.M. Vrijkotte, Alet H. Wijga, Manolis Kogevinas, Maurice P. Zeegers, Lyda Chatzi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Results: The median fish consumption during pregnancy ranged from 0.44 times/week in The Netherlands to 4.46 times/week in Spain. Maternal fish intake during pregnancy was not associated with offspring wheeze symptoms in any age group nor with the risk of child asthma [adjusted meta-analysis relative risk (RR) per 1-time/week = 1.01, 95% confidence interval 0.97-1.05)] and allergic rhinitis at school age (RR = 1.01, 0.99-1.03). These results were consistently found in further analyses by type of fish and seafood consumption and in sensitivity analyses. Conclusion: We found no evidence supporting a protective association of fish and seafood consumption during pregnancy with offspring symptoms of wheeze, asthma and allergic rhinitis from infancy to mid childhood.
Original languageEnglish
Pages (from-to)1465-1477
Number of pages13
JournalInternational Journal of Epidemiology
Volume46
Issue number5
DOIs
Publication statusPublished - Oct 2017

Fingerprint

Seafood
Fishes
Asthma
Parturition
Pregnancy
Meta-Analysis
Cohort Studies
Mothers
Allergic Rhinitis
Rhinitis
Netherlands
Spain
Hypersensitivity
Fatty Acids
Age Groups
Confidence Intervals

Keywords

  • wheezing
  • allergic rhinitis
  • asthma
  • children
  • fish
  • pregnancy
  • seafood

Cite this

Stratakis, Nikos ; Roumeliotaki, Theano ; Oken, Emily ; Ballester, Ferran ; Barros, Henrique ; Basterrechea, Mikel ; Cordier, Sylvaine ; De Groot, Renate ; de Dekker, Herman T. ; Duijts, Liesbeth ; Eggesbø, Merete ; Fantini, Maria Pia ; Forastiere, Francesco ; Gehring, Ulrike ; Gielen, Marij ; Gori, Davide ; Govarts, Eva ; Inskip, Hazel M. ; Iszatt, Nina ; Jansen, Maria ; Kelleher, Cecily ; Mehegan, John ; Moltó-Puigmartí, Carolina ; Mommers, Monique ; Oliveira, Andrea ; Olsen, Sjurdur F. ; Pelé, Fabienne ; Pizzi, Constanza ; Porta, Daniela ; Richiardi, Lorenzo ; Rifas-Shiman, Sheryl L. ; Robinson, Sian M. ; Schoeters, Greet ; Strøm, Marin ; Sunyer, Jordi ; Thijs, Carel ; Vrijheid, Martine ; Vrijkotte, Tanja G.M. ; Wijga, Alet H. ; Kogevinas, Manolis ; Zeegers, Maurice P. ; Chatzi, Lyda. / Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood : A pooled analysis of 18 European and US birth cohorts. In: International Journal of Epidemiology. 2017 ; Vol. 46, No. 5. pp. 1465-1477.
@article{8a5bbfd460d248479af9e7d79fa9f10e,
title = "Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: A pooled analysis of 18 European and US birth cohorts",
abstract = "Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Results: The median fish consumption during pregnancy ranged from 0.44 times/week in The Netherlands to 4.46 times/week in Spain. Maternal fish intake during pregnancy was not associated with offspring wheeze symptoms in any age group nor with the risk of child asthma [adjusted meta-analysis relative risk (RR) per 1-time/week = 1.01, 95{\%} confidence interval 0.97-1.05)] and allergic rhinitis at school age (RR = 1.01, 0.99-1.03). These results were consistently found in further analyses by type of fish and seafood consumption and in sensitivity analyses. Conclusion: We found no evidence supporting a protective association of fish and seafood consumption during pregnancy with offspring symptoms of wheeze, asthma and allergic rhinitis from infancy to mid childhood.",
keywords = "wheezing, allergic rhinitis, asthma, children, fish, pregnancy, seafood",
author = "Nikos Stratakis and Theano Roumeliotaki and Emily Oken and Ferran Ballester and Henrique Barros and Mikel Basterrechea and Sylvaine Cordier and {De Groot}, Renate and {de Dekker}, {Herman T.} and Liesbeth Duijts and Merete Eggesb{\o} and Fantini, {Maria Pia} and Francesco Forastiere and Ulrike Gehring and Marij Gielen and Davide Gori and Eva Govarts and Inskip, {Hazel M.} and Nina Iszatt and Maria Jansen and Cecily Kelleher and John Mehegan and Carolina Molt{\'o}-Puigmart{\'i} and Monique Mommers and Andrea Oliveira and Olsen, {Sjurdur F.} and Fabienne Pel{\'e} and Constanza Pizzi and Daniela Porta and Lorenzo Richiardi and Rifas-Shiman, {Sheryl L.} and Robinson, {Sian M.} and Greet Schoeters and Marin Str{\o}m and Jordi Sunyer and Carel Thijs and Martine Vrijheid and Vrijkotte, {Tanja G.M.} and Wijga, {Alet H.} and Manolis Kogevinas and Zeegers, {Maurice P.} and Lyda Chatzi",
note = "DS_Citation:Stratakis N, Roumeliotaki T, Oken E, Ballester F, Barros H, Basterrechea M, Cordier S, de Groot R, den Dekker TH, Duijts L, Eggesb{\o} E, Fantini MP, Forastiere F, Gehring U, Gielen M, Gori D, Govarts E, Inskip MH, Iszatt I, Jansen M, Kelleher C, Mehegan J, Molt{\'o}-Puigmart{\'i} C, Mommers M, Oliveira A, Olsen FS, Pel{\'e} F, Pizzi C, Porta D, Richiardi L, Rifas-Shiman LS, Robinson MS, Schoeters G, Str{\o}m M, Sunyer J, Thijs C, Vrijheid M, Vrijkotte GMT, Wijga HA, Kogevinas M, Zeegers PM, Chatzi L. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts. Int J Epidemiol, 46, 5, 1465.",
year = "2017",
month = "10",
doi = "10.1093/ije/dyx007",
language = "English",
volume = "46",
pages = "1465--1477",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "5",

}

Stratakis, N, Roumeliotaki, T, Oken, E, Ballester, F, Barros, H, Basterrechea, M, Cordier, S, De Groot, R, de Dekker, HT, Duijts, L, Eggesbø, M, Fantini, MP, Forastiere, F, Gehring, U, Gielen, M, Gori, D, Govarts, E, Inskip, HM, Iszatt, N, Jansen, M, Kelleher, C, Mehegan, J, Moltó-Puigmartí, C, Mommers, M, Oliveira, A, Olsen, SF, Pelé, F, Pizzi, C, Porta, D, Richiardi, L, Rifas-Shiman, SL, Robinson, SM, Schoeters, G, Strøm, M, Sunyer, J, Thijs, C, Vrijheid, M, Vrijkotte, TGM, Wijga, AH, Kogevinas, M, Zeegers, MP & Chatzi, L 2017, 'Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: A pooled analysis of 18 European and US birth cohorts', International Journal of Epidemiology, vol. 46, no. 5, pp. 1465-1477. https://doi.org/10.1093/ije/dyx007

Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood : A pooled analysis of 18 European and US birth cohorts. / Stratakis, Nikos; Roumeliotaki, Theano; Oken, Emily; Ballester, Ferran; Barros, Henrique; Basterrechea, Mikel; Cordier, Sylvaine; De Groot, Renate; de Dekker, Herman T.; Duijts, Liesbeth; Eggesbø, Merete; Fantini, Maria Pia; Forastiere, Francesco; Gehring, Ulrike; Gielen, Marij; Gori, Davide; Govarts, Eva; Inskip, Hazel M.; Iszatt, Nina; Jansen, Maria; Kelleher, Cecily; Mehegan, John; Moltó-Puigmartí, Carolina; Mommers, Monique; Oliveira, Andrea; Olsen, Sjurdur F.; Pelé, Fabienne; Pizzi, Constanza; Porta, Daniela; Richiardi, Lorenzo; Rifas-Shiman, Sheryl L.; Robinson, Sian M.; Schoeters, Greet; Strøm, Marin; Sunyer, Jordi; Thijs, Carel; Vrijheid, Martine; Vrijkotte, Tanja G.M.; Wijga, Alet H.; Kogevinas, Manolis; Zeegers, Maurice P.; Chatzi, Lyda.

In: International Journal of Epidemiology, Vol. 46, No. 5, 10.2017, p. 1465-1477.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood

T2 - A pooled analysis of 18 European and US birth cohorts

AU - Stratakis, Nikos

AU - Roumeliotaki, Theano

AU - Oken, Emily

AU - Ballester, Ferran

AU - Barros, Henrique

AU - Basterrechea, Mikel

AU - Cordier, Sylvaine

AU - De Groot, Renate

AU - de Dekker, Herman T.

AU - Duijts, Liesbeth

AU - Eggesbø, Merete

AU - Fantini, Maria Pia

AU - Forastiere, Francesco

AU - Gehring, Ulrike

AU - Gielen, Marij

AU - Gori, Davide

AU - Govarts, Eva

AU - Inskip, Hazel M.

AU - Iszatt, Nina

AU - Jansen, Maria

AU - Kelleher, Cecily

AU - Mehegan, John

AU - Moltó-Puigmartí, Carolina

AU - Mommers, Monique

AU - Oliveira, Andrea

AU - Olsen, Sjurdur F.

AU - Pelé, Fabienne

AU - Pizzi, Constanza

AU - Porta, Daniela

AU - Richiardi, Lorenzo

AU - Rifas-Shiman, Sheryl L.

AU - Robinson, Sian M.

AU - Schoeters, Greet

AU - Strøm, Marin

AU - Sunyer, Jordi

AU - Thijs, Carel

AU - Vrijheid, Martine

AU - Vrijkotte, Tanja G.M.

AU - Wijga, Alet H.

AU - Kogevinas, Manolis

AU - Zeegers, Maurice P.

AU - Chatzi, Lyda

N1 - DS_Citation:Stratakis N, Roumeliotaki T, Oken E, Ballester F, Barros H, Basterrechea M, Cordier S, de Groot R, den Dekker TH, Duijts L, Eggesbø E, Fantini MP, Forastiere F, Gehring U, Gielen M, Gori D, Govarts E, Inskip MH, Iszatt I, Jansen M, Kelleher C, Mehegan J, Moltó-Puigmartí C, Mommers M, Oliveira A, Olsen FS, Pelé F, Pizzi C, Porta D, Richiardi L, Rifas-Shiman LS, Robinson MS, Schoeters G, Strøm M, Sunyer J, Thijs C, Vrijheid M, Vrijkotte GMT, Wijga HA, Kogevinas M, Zeegers PM, Chatzi L. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts. Int J Epidemiol, 46, 5, 1465.

PY - 2017/10

Y1 - 2017/10

N2 - Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Results: The median fish consumption during pregnancy ranged from 0.44 times/week in The Netherlands to 4.46 times/week in Spain. Maternal fish intake during pregnancy was not associated with offspring wheeze symptoms in any age group nor with the risk of child asthma [adjusted meta-analysis relative risk (RR) per 1-time/week = 1.01, 95% confidence interval 0.97-1.05)] and allergic rhinitis at school age (RR = 1.01, 0.99-1.03). These results were consistently found in further analyses by type of fish and seafood consumption and in sensitivity analyses. Conclusion: We found no evidence supporting a protective association of fish and seafood consumption during pregnancy with offspring symptoms of wheeze, asthma and allergic rhinitis from infancy to mid childhood.

AB - Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Results: The median fish consumption during pregnancy ranged from 0.44 times/week in The Netherlands to 4.46 times/week in Spain. Maternal fish intake during pregnancy was not associated with offspring wheeze symptoms in any age group nor with the risk of child asthma [adjusted meta-analysis relative risk (RR) per 1-time/week = 1.01, 95% confidence interval 0.97-1.05)] and allergic rhinitis at school age (RR = 1.01, 0.99-1.03). These results were consistently found in further analyses by type of fish and seafood consumption and in sensitivity analyses. Conclusion: We found no evidence supporting a protective association of fish and seafood consumption during pregnancy with offspring symptoms of wheeze, asthma and allergic rhinitis from infancy to mid childhood.

KW - wheezing

KW - allergic rhinitis

KW - asthma

KW - children

KW - fish

KW - pregnancy

KW - seafood

U2 - 10.1093/ije/dyx007

DO - 10.1093/ije/dyx007

M3 - Article

VL - 46

SP - 1465

EP - 1477

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 5

ER -