@article{8a5bbfd460d248479af9e7d79fa9f10e,
title = "Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: A pooled analysis of 18 European and US birth cohorts",
abstract = "Background: It has been suggested that prenatal exposure to n-3 long-chain fatty acids protects against asthma and other allergy-related diseases later in childhood. The extent to which fish intake in pregnancy protects against child asthma and rhinitis symptoms remains unclear. We aimed to assess whether fish and seafood consumption in pregnancy is associated with childhood wheeze, asthma and allergic rhinitis. Methods: We pooled individual data from 60 774 mother-child pairs participating in 18 European and US birth cohort studies. Information on wheeze, asthma and allergic rhinitis prevalence was collected using validated questionnaires. The time periods of interest were: infancy (0-2 years), preschool age (3-4 years), and school age (5-8 years). We used multivariable generalized models to assess associations of fish and seafood (other than fish) consumption during pregnancy with child respiratory outcomes in cohort-specific analyses, with subsequent random-effects meta-analyses. Results: The median fish consumption during pregnancy ranged from 0.44 times/week in The Netherlands to 4.46 times/week in Spain. Maternal fish intake during pregnancy was not associated with offspring wheeze symptoms in any age group nor with the risk of child asthma [adjusted meta-analysis relative risk (RR) per 1-time/week = 1.01, 95% confidence interval 0.97-1.05)] and allergic rhinitis at school age (RR = 1.01, 0.99-1.03). These results were consistently found in further analyses by type of fish and seafood consumption and in sensitivity analyses. Conclusion: We found no evidence supporting a protective association of fish and seafood consumption during pregnancy with offspring symptoms of wheeze, asthma and allergic rhinitis from infancy to mid childhood.",
keywords = "wheezing, allergic rhinitis, asthma, children, fish, pregnancy, seafood",
author = "Nikos Stratakis and Theano Roumeliotaki and Emily Oken and Ferran Ballester and Henrique Barros and Mikel Basterrechea and Sylvaine Cordier and {De Groot}, Renate and {de Dekker}, {Herman T.} and Liesbeth Duijts and Merete Eggesb{\o} and Fantini, {Maria Pia} and Francesco Forastiere and Ulrike Gehring and Marij Gielen and Davide Gori and Eva Govarts and Inskip, {Hazel M.} and Nina Iszatt and Maria Jansen and Cecily Kelleher and John Mehegan and Carolina Molt{\'o}-Puigmart{\'i} and Monique Mommers and Andrea Oliveira and Olsen, {Sjurdur F.} and Fabienne Pel{\'e} and Constanza Pizzi and Daniela Porta and Lorenzo Richiardi and Rifas-Shiman, {Sheryl L.} and Robinson, {Sian M.} and Greet Schoeters and Marin Str{\o}m and Jordi Sunyer and Carel Thijs and Martine Vrijheid and Vrijkotte, {Tanja G.M.} and Wijga, {Alet H.} and Manolis Kogevinas and Zeegers, {Maurice P.} and Lyda Chatzi",
note = "DS_Citation:Stratakis N, Roumeliotaki T, Oken E, Ballester F, Barros H, Basterrechea M, Cordier S, de Groot R, den Dekker TH, Duijts L, Eggesb{\o} E, Fantini MP, Forastiere F, Gehring U, Gielen M, Gori D, Govarts E, Inskip MH, Iszatt I, Jansen M, Kelleher C, Mehegan J, Molt{\'o}-Puigmart{\'i} C, Mommers M, Oliveira A, Olsen FS, Pel{\'e} F, Pizzi C, Porta D, Richiardi L, Rifas-Shiman LS, Robinson MS, Schoeters G, Str{\o}m M, Sunyer J, Thijs C, Vrijheid M, Vrijkotte GMT, Wijga HA, Kogevinas M, Zeegers PM, Chatzi L. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts. Int J Epidemiol, 46, 5, 1465.",
year = "2017",
month = oct,
doi = "10.1093/ije/dyx007",
language = "English",
volume = "46",
pages = "1465--1477",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "5",
}