Mechanistically-based QSARs to Describe Metabolic Constants in Mammals

Alessandra Pirovano*, Mark A. J. Huijbregts, Ad M. J. Ragas, Karin Veltman, A. Jan Hendriks

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)59-69
Number of pages11
JournalATLA-Alternatives to laboratory animals
Volume42
Issue number1
DOIs
Publication statusPublished - 1 Mar 2014

Keywords

  • biotransformation
  • K-m
  • QSAR
  • V-max
  • QUANTITATIVE STRUCTURE-ACTIVITY
  • DRUG-METABOLISM
  • ALDEHYDE DEHYDROGENASES
  • COMPOUND LIPOPHILICITY
  • PREDICTING METABOLISM
  • HUMAN P450S
  • CYTOCHROME-P450
  • TOXICITY
  • BINDING
  • DESCRIPTORS

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