Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation

Kate Xu, Darya Gaysina, Roula Tsonaka, Alexandre Morin, Tim Croudace, Jennier Barnett, Jeanine Houwing-Duistermaat, Marcus Richards, Peter Jones, The LHA Genetics Group

Research output: Contribution to journalArticleAcademicpeer-review

1 Downloads (Pure)

Abstract

Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β = −0.167; CI: −0.289, −0.045; p = 0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β = 0.197; CI: 0.067, 0.328; p = 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although, we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modeling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.
Original languageEnglish
Article number1736
Number of pages13
JournalFrontiers in Psychologie
Volume8
Issue number1736
DOIs
Publication statusPublished - 11 Oct 2017

Fingerprint

Monoamine Oxidase
Personality
Phenotype
Genes
Molecular Biology
Health Surveys
Psychometrics
Single Nucleotide Polymorphism
Parturition
Psychology
Extraversion (Psychology)
Neuroticism

Keywords

  • latent variable
  • MAOA
  • personality
  • development
  • adolescents
  • GENOME-WIDE ASSOCIATION
  • FAMILY-BASED ASSOCIATION
  • OF-FIT INDEXES
  • FUNCTIONAL POLYMORPHISM
  • A GENE
  • LONGITUDINAL DATA
  • ENVIRONMENT INTERACTIONS
  • MEASUREMENT INVARIANCE
  • PROMOTER POLYMORPHISM
  • ANTISOCIAL-BEHAVIOR

Cite this

Xu, Kate ; Gaysina, Darya ; Tsonaka, Roula ; Morin, Alexandre ; Croudace, Tim ; Barnett, Jennier ; Houwing-Duistermaat, Jeanine ; Richards, Marcus ; Jones, Peter ; The LHA Genetics Group. / Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. In: Frontiers in Psychologie. 2017 ; Vol. 8, No. 1736.
@article{e244088a2ce04e5eb2857f03719c1d9c,
title = "Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation",
abstract = "Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β = −0.167; CI: −0.289, −0.045; p = 0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β = 0.197; CI: 0.067, 0.328; p = 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although, we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modeling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.",
keywords = "latent variable, MAOA, personality, development, adolescents, GENOME-WIDE ASSOCIATION, FAMILY-BASED ASSOCIATION, OF-FIT INDEXES, FUNCTIONAL POLYMORPHISM, A GENE, LONGITUDINAL DATA, ENVIRONMENT INTERACTIONS, MEASUREMENT INVARIANCE, PROMOTER POLYMORPHISM, ANTISOCIAL-BEHAVIOR",
author = "Kate Xu and Darya Gaysina and Roula Tsonaka and Alexandre Morin and Tim Croudace and Jennier Barnett and Jeanine Houwing-Duistermaat and Marcus Richards and Peter Jones and {The LHA Genetics Group}",
year = "2017",
month = "10",
day = "11",
doi = "10.3389/fpsyg.2017.01736",
language = "English",
volume = "8",
journal = "Frontiers in Psychologie",
publisher = "Fronteris in Psychology",
number = "1736",

}

Xu, K, Gaysina, D, Tsonaka, R, Morin, A, Croudace, T, Barnett, J, Houwing-Duistermaat, J, Richards, M, Jones, P & The LHA Genetics Group 2017, 'Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation', Frontiers in Psychologie, vol. 8, no. 1736, 1736. https://doi.org/10.3389/fpsyg.2017.01736

Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation. / Xu, Kate; Gaysina, Darya; Tsonaka, Roula; Morin, Alexandre; Croudace, Tim; Barnett, Jennier; Houwing-Duistermaat, Jeanine; Richards, Marcus; Jones, Peter; The LHA Genetics Group.

In: Frontiers in Psychologie, Vol. 8, No. 1736, 1736, 11.10.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Monoamine Oxidase A (MAOA) Gene and Personality Traits from Late Adolescence through Early Adulthood: A Latent Variable Investigation

AU - Xu, Kate

AU - Gaysina, Darya

AU - Tsonaka, Roula

AU - Morin, Alexandre

AU - Croudace, Tim

AU - Barnett, Jennier

AU - Houwing-Duistermaat, Jeanine

AU - Richards, Marcus

AU - Jones, Peter

AU - The LHA Genetics Group, null

PY - 2017/10/11

Y1 - 2017/10/11

N2 - Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β = −0.167; CI: −0.289, −0.045; p = 0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β = 0.197; CI: 0.067, 0.328; p = 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although, we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modeling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.

AB - Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD). The predictor variable was based on a latent variable representing genetic variations of the MAOA gene measured by three SNPs (rs3788862, rs5906957, and rs979606). Latent phenotype variables were constructed using psychometric methods to represent cross-sectional and longitudinal phenotypes of extraversion and neuroticism measured at ages 16 and 26. In males, the MAOA genetic latent variable (AAG) was associated with lower extraversion score at age 16 (β = −0.167; CI: −0.289, −0.045; p = 0.007, FDRp = 0.042), as well as greater increase in extraversion score from 16 to 26 years (β = 0.197; CI: 0.067, 0.328; p = 0.003, FDRp = 0.036). No genetic association was found for neuroticism after adjustment for multiple testing. Although, we did not find statistically significant associations after multiple testing correction in females, this result needs to be interpreted with caution due to issues related to x-inactivation in females. The latent variable method is an effective way of modeling phenotype- and genetic-based variances and may therefore improve the methodology of molecular genetic studies of complex psychological traits.

KW - latent variable

KW - MAOA

KW - personality

KW - development

KW - adolescents

KW - GENOME-WIDE ASSOCIATION

KW - FAMILY-BASED ASSOCIATION

KW - OF-FIT INDEXES

KW - FUNCTIONAL POLYMORPHISM

KW - A GENE

KW - LONGITUDINAL DATA

KW - ENVIRONMENT INTERACTIONS

KW - MEASUREMENT INVARIANCE

KW - PROMOTER POLYMORPHISM

KW - ANTISOCIAL-BEHAVIOR

U2 - 10.3389/fpsyg.2017.01736

DO - 10.3389/fpsyg.2017.01736

M3 - Article

VL - 8

JO - Frontiers in Psychologie

JF - Frontiers in Psychologie

IS - 1736

M1 - 1736

ER -