Nitric Oxide Mediates Crosstalk between Interleukin 1β and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression

Leilei Zhong, Stefano Schivo, Xiaobin Huang, Jeroen Leijten, Marcel Karperien, Janine N Post*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number2491
Number of pages18
JournalInternational Journal of Molecular Sciences
Volume18
Issue number11
DOIs
Publication statusPublished - 22 Nov 2017
Externally publishedYes

Keywords

  • osteoarthritis
  • cell signaling
  • IL1
  • WNT
  • antagonists
  • computational modeling
  • nitric oxide
  • FRIZZLED-RELATED PROTEIN
  • HUMAN ARTICULAR CHONDROCYTES
  • GENE-EXPRESSION
  • EXPERIMENTAL OSTEOARTHRITIS
  • SELECTIVE-INHIBITION
  • HIP OSTEOARTHRITIS
  • CARTILAGE
  • CATENIN
  • TRANSCRIPTION
  • HYPERTROPHY

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