Polygenic liability for schizophrenia and childhood adversity influences daily-life emotion dysregulation and psychosis proneness

Lotta-Katrin Pries, B Klingenberg, Claudia Menne-Lothmann, Jeroen Decoster, R van Winkel, D. Collip, P Delespaul, Marc de Hert, Cathérine Derom, Evert Thiery, N.E. Jacobs, M Wichers, O Cinar, B.D. Lin, J. J. Luykx, B. P. F. Rutten, J. van Os, S. Guloksuz

Research output: Contribution to journalArticleAcademicpeer-review


Objective: To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures. Methods: The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models. Results: Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene–environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = −0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures. Conclusion: Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.

Original languageEnglish
Pages (from-to)465-475
Number of pages11
JournalActa Psychiatrica Scandinavica
Issue number5
Publication statusPublished - 1 May 2020


  • childhood trauma
  • daily-life stressors
  • emotion regulation
  • experience sampling method
  • gene–environment interaction
  • psychosis


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