Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth

An-Sofie Stevens, Nicky Pirotte, Annelies Wouters, Andromeda Van Roten, Frank Van Belleghem, Maxime Willems, Ann Cuypers, Tom Artois, Karen Smeets*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells.

Original languageEnglish
Pages (from-to)1414-1437
Number of pages24
JournalCurrent Drug Targets
Volume17
Issue number12
DOIs
Publication statusPublished - 2016

Keywords

  • Anticarcinogenic therapies
  • carcinogenesis
  • redox-related mechanisms
  • regeneration
  • stem cells
  • NF-KAPPA-B
  • EPITHELIAL-MESENCHYMAL TRANSITION
  • OXYGEN SPECIES ACCUMULATION
  • AXON REGENERATION REQUIRES
  • INDUCIBLE FACTOR 1-ALPHA
  • INHIBITS TUMOR-GROWTH
  • OXIDATIVE STRESS
  • BREAST-CANCER
  • STEM-CELLS
  • PLANARIAN REGENERATION

Cite this

Stevens, A-S., Pirotte, N., Wouters, A., Van Roten, A., Van Belleghem, F., Willems, M., Cuypers, A., Artois, T., & Smeets, K. (2016). Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth. Current Drug Targets, 17(12), 1414-1437. https://doi.org/10.2174/1389450116666150506112817