Separating uncertainty and physiological variability in human PBPK modelling: The example of 2-propanol and its metabolite acetone

Daan Huizer*, Rik Oldenkamp, Ad M. J. Ragas, Joost G. M. van Rooij, Mark A. J. Huijbregts

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    13 Citations (Web of Science)
    Original languageEnglish
    Pages (from-to)154-165
    Number of pages12
    JournalToxicology Letters
    Volume214
    Issue number2
    DOIs
    Publication statusPublished - 17 Oct 2012

    Keywords

    • Uncertainty
    • Variability
    • Nested Monte Carlo
    • PBPK model
    • 2-Propanol
    • Acetone
    • PHARMACOKINETIC MODEL
    • PARTITION-COEFFICIENTS
    • RISK-ASSESSMENT
    • SENSITIVITY-ANALYSIS
    • ORGANIC-COMPOUNDS
    • PHYSICOCHEMICAL PROPERTIES
    • SOLUBILITY PROPERTIES
    • BIOLOGICAL MEDIA
    • AROMATIC SOLUTES
    • BLOOD

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