Serum S100B

A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder?

Christine van der Leeuw*, Sanne Peeters, Ed Gronenschild, Stijn Michielse, Marcel Verbeek, Paul Menheere, Jim van Os, Machteld Marcelis, Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

S100B is a protein with dose-dependent neurotrophic and neurotoxic effects. Whether S100B in psychotic disorder mirrors pathophysiological mechanisms (which elicit exacerbation of disease) or compensatory action is unclear, as is its validity as a proxy marker for brain status. Insight may be gained by examining associations between serum S100B and indices of grey (cortical thickness (CT)) and white matter (fractional anisotropy (FA)), in relation to the absence or presence of (increased risk of) psychotic disorder. Blood samples and cerebral magnetic resonance imaging (MRI) scans were acquired in 32 patients with psychotic disorder, 44 non-psychotic siblings of patients with psychotic disorder and 26 controls. Interactions between S100B and group were examined in separate models of CT and FA measures with multilevel regression analyses weighted for number of vertices and voxels (i.e. units of volume) respectively. All analyses were adjusted for sex, age, body mass index (BMI), scan sequence, handedness and highest level of education. Neither CT nor FA was associated with S100B. There were no significant S100B × group interactions (CT: χ2 = 0.044, p = 0.978; FA: χ2 = 3.672, p = 0.159). No evidence was present for S100B as a proxy marker of grey or white matter status. The association between S100B and brain measures was not moderated by psychosis risk.

Original languageEnglish
Article number0174752
Number of pages11
JournalPLOS ONE
Volume12
Issue number3
DOIs
Publication statusPublished - 30 Mar 2017

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Status Epilepticus
Proxy
blood serum
Psychotic Disorders
Anisotropy
Serum
Brain
brain
educational status
Magnetic resonance
Multilevel Analysis
Functional Laterality
magnetic resonance imaging
body mass index
Blood
Education
Disease Progression
Siblings
Imaging techniques
Body Mass Index

Keywords

  • HUMAN CEREBRAL-CORTEX
  • COGNITIVE RECOVERY
  • BRAIN
  • SCHIZOPHRENIA
  • ENVIRONMENT
  • SYMPTOMS
  • INFUSION
  • SYSTEM
  • INJURY
  • MRI

Cite this

van der Leeuw, C., Peeters, S., Gronenschild, E., Michielse, S., Verbeek, M., Menheere, P., ... Genetic Risk and Outcome of Psychosis (G.R.O.U.P.) (2017). Serum S100B: A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder? PLOS ONE, 12(3), [0174752]. https://doi.org/10.1371/journal.pone.0174752
van der Leeuw, Christine ; Peeters, Sanne ; Gronenschild, Ed ; Michielse, Stijn ; Verbeek, Marcel ; Menheere, Paul ; van Os, Jim ; Marcelis, Machteld ; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.). / Serum S100B : A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder?. In: PLOS ONE. 2017 ; Vol. 12, No. 3.
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title = "Serum S100B: A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder?",
abstract = "S100B is a protein with dose-dependent neurotrophic and neurotoxic effects. Whether S100B in psychotic disorder mirrors pathophysiological mechanisms (which elicit exacerbation of disease) or compensatory action is unclear, as is its validity as a proxy marker for brain status. Insight may be gained by examining associations between serum S100B and indices of grey (cortical thickness (CT)) and white matter (fractional anisotropy (FA)), in relation to the absence or presence of (increased risk of) psychotic disorder. Blood samples and cerebral magnetic resonance imaging (MRI) scans were acquired in 32 patients with psychotic disorder, 44 non-psychotic siblings of patients with psychotic disorder and 26 controls. Interactions between S100B and group were examined in separate models of CT and FA measures with multilevel regression analyses weighted for number of vertices and voxels (i.e. units of volume) respectively. All analyses were adjusted for sex, age, body mass index (BMI), scan sequence, handedness and highest level of education. Neither CT nor FA was associated with S100B. There were no significant S100B × group interactions (CT: χ2 = 0.044, p = 0.978; FA: χ2 = 3.672, p = 0.159). No evidence was present for S100B as a proxy marker of grey or white matter status. The association between S100B and brain measures was not moderated by psychosis risk.",
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van der Leeuw, C, Peeters, S, Gronenschild, E, Michielse, S, Verbeek, M, Menheere, P, van Os, J, Marcelis, M & Genetic Risk and Outcome of Psychosis (G.R.O.U.P.) 2017, 'Serum S100B: A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder?', PLOS ONE, vol. 12, no. 3, 0174752. https://doi.org/10.1371/journal.pone.0174752

Serum S100B : A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder? / van der Leeuw, Christine; Peeters, Sanne; Gronenschild, Ed; Michielse, Stijn; Verbeek, Marcel; Menheere, Paul; van Os, Jim; Marcelis, Machteld; Genetic Risk and Outcome of Psychosis (G.R.O.U.P.).

In: PLOS ONE, Vol. 12, No. 3, 0174752, 30.03.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Serum S100B

T2 - A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder?

AU - van der Leeuw, Christine

AU - Peeters, Sanne

AU - Gronenschild, Ed

AU - Michielse, Stijn

AU - Verbeek, Marcel

AU - Menheere, Paul

AU - van Os, Jim

AU - Marcelis, Machteld

AU - Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)

PY - 2017/3/30

Y1 - 2017/3/30

N2 - S100B is a protein with dose-dependent neurotrophic and neurotoxic effects. Whether S100B in psychotic disorder mirrors pathophysiological mechanisms (which elicit exacerbation of disease) or compensatory action is unclear, as is its validity as a proxy marker for brain status. Insight may be gained by examining associations between serum S100B and indices of grey (cortical thickness (CT)) and white matter (fractional anisotropy (FA)), in relation to the absence or presence of (increased risk of) psychotic disorder. Blood samples and cerebral magnetic resonance imaging (MRI) scans were acquired in 32 patients with psychotic disorder, 44 non-psychotic siblings of patients with psychotic disorder and 26 controls. Interactions between S100B and group were examined in separate models of CT and FA measures with multilevel regression analyses weighted for number of vertices and voxels (i.e. units of volume) respectively. All analyses were adjusted for sex, age, body mass index (BMI), scan sequence, handedness and highest level of education. Neither CT nor FA was associated with S100B. There were no significant S100B × group interactions (CT: χ2 = 0.044, p = 0.978; FA: χ2 = 3.672, p = 0.159). No evidence was present for S100B as a proxy marker of grey or white matter status. The association between S100B and brain measures was not moderated by psychosis risk.

AB - S100B is a protein with dose-dependent neurotrophic and neurotoxic effects. Whether S100B in psychotic disorder mirrors pathophysiological mechanisms (which elicit exacerbation of disease) or compensatory action is unclear, as is its validity as a proxy marker for brain status. Insight may be gained by examining associations between serum S100B and indices of grey (cortical thickness (CT)) and white matter (fractional anisotropy (FA)), in relation to the absence or presence of (increased risk of) psychotic disorder. Blood samples and cerebral magnetic resonance imaging (MRI) scans were acquired in 32 patients with psychotic disorder, 44 non-psychotic siblings of patients with psychotic disorder and 26 controls. Interactions between S100B and group were examined in separate models of CT and FA measures with multilevel regression analyses weighted for number of vertices and voxels (i.e. units of volume) respectively. All analyses were adjusted for sex, age, body mass index (BMI), scan sequence, handedness and highest level of education. Neither CT nor FA was associated with S100B. There were no significant S100B × group interactions (CT: χ2 = 0.044, p = 0.978; FA: χ2 = 3.672, p = 0.159). No evidence was present for S100B as a proxy marker of grey or white matter status. The association between S100B and brain measures was not moderated by psychosis risk.

KW - HUMAN CEREBRAL-CORTEX

KW - COGNITIVE RECOVERY

KW - BRAIN

KW - SCHIZOPHRENIA

KW - ENVIRONMENT

KW - SYMPTOMS

KW - INFUSION

KW - SYSTEM

KW - INJURY

KW - MRI

U2 - 10.1371/journal.pone.0174752

DO - 10.1371/journal.pone.0174752

M3 - Article

VL - 12

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 3

M1 - 0174752

ER -