Testing the coherence between occupational exposure limits for inhalation and their biological limit values with a generalized PBPK-model: The case of 2-propanol and acetone

Daan Huizer*, Mark A. J. Huijbregts, Joost G. M. van Rooij, Ad M. J. Ragas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)408-415
Number of pages8
JournalRegulatory Toxicology and Pharmacology
Volume69
Issue number3
Early online date20 May 2014
DOIs
Publication statusPublished - Aug 2014

Keywords

  • Coherence
  • Occupational exposure limits
  • Biological limit values
  • PBPK model
  • 2-Propanol
  • Acetone
  • Uncertainty
  • Variability
  • PHARMACOKINETIC MODEL
  • BIOMONITORING EQUIVALENTS
  • METABOLITE ACETONE
  • HUMAN VARIABILITY
  • UNCERTAINTY
  • URINE
  • ELIMINATION
  • SIMULATION
  • DERIVATION
  • INDEXES

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