TY - JOUR
T1 - The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time
T2 - a prospective cohort study
AU - Schoenmakers, Tom
AU - Leers, Mathie P. G.
AU - Gorissen, Stefan H. M.
AU - Loo, Inge H. M. van
AU - Rosmalen, Frank van
AU - Aydeniz, Eda
AU - Schellens, Joep
AU - Driessen, Marielle
AU - Deneer, Ruben
AU - Venne, Wilhelmine P. H. G. Verboeket-van de
AU - Wolffs, Petra F. G.
AU - Mook, Walther N. K. A. van
AU - Bussel, Bas C. T. van
AU - Ament, Stephanie
AU - Arbous, M. Sesmu
AU - Bekers, Otto
AU - Berckel, Miranda van
AU - Boer, Arjan-Kars
AU - Dam, Dirk W. van
AU - Deneer, Ruben
AU - Doorn, William P. T. M. van
AU - Dormans, Tom P.
AU - Evers, Silvia M. M. A.
AU - Frenzel, Tim
AU - Geus-Bosma, Madeleen de
AU - Gillis, Judith
AU - Horst, Iwan C. C. van der
AU - Koek, W. Nadia H.
AU - Linssen, Kitty
AU - Meex, Steven J. R.
AU - Mostard, Guy J. M.
AU - Mostard, Remy L. M.
AU - Otterspoor, Luuk C.
AU - Riel, Natal A. W. van
AU - Stals, Frans
AU - Westreenen, Harro van
AU - Wolthuis, Albert
AU - Mastrigt, Ghislaine van
AU - Peeters, Andrea
AU - the CoLaIC-consortium
PY - 2024
Y1 - 2024
N2 - The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95% CI − 0.33 to − 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (− 0.01 (95% CI − 0.01 to − 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.
AB - The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95% CI − 0.33 to − 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (− 0.01 (95% CI − 0.01 to − 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.
U2 - 10.1038/s41598-024-58727-y
DO - 10.1038/s41598-024-58727-y
M3 - Article
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
M1 - 8220
ER -