The utilisation of structural descriptors to predict metabolic constants of xenobiotics in mammals

Alessandra Pirovano*, Stefan Brandmaier, Mark A. J. Huijbregts, Ad M. J. Ragas, Karin Veltman, A. Jan Hendriks

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)247-258
Number of pages12
JournalEnvironmental Toxicology and Pharmacology
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Quantitative structure activity relationship
  • Biotransformation
  • Michaelis-Menten constant (K-m)
  • Maximum reaction rate (V-max)
  • COMPOUND LIPOPHILICITY
  • DRUG-METABOLISM
  • QSAR
  • CYTOCHROME-P450
  • APPLICABILITY
  • CHEMISTRY
  • CHEMICALS
  • TOXICITY
  • PITFALLS
  • PROGRAM

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