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The utilisation of structural descriptors to predict metabolic constants of xenobiotics in mammals

  • Alessandra Pirovano*
  • , Stefan Brandmaier
  • , Mark A. J. Huijbregts
  • , Ad M. J. Ragas
  • , Karin Veltman
  • , A. Jan Hendriks
  • *Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Original languageEnglish
Pages (from-to)247-258
Number of pages12
JournalEnvironmental Toxicology and Pharmacology
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Quantitative structure activity relationship
  • Biotransformation
  • Michaelis-Menten constant (K-m)
  • Maximum reaction rate (V-max)
  • COMPOUND LIPOPHILICITY
  • DRUG-METABOLISM
  • QSAR
  • CYTOCHROME-P450
  • APPLICABILITY
  • CHEMISTRY
  • CHEMICALS
  • TOXICITY
  • PITFALLS
  • PROGRAM

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